The four-helix bundle is a simple structural motif, widespread in nature, that is involved in numerous and fundamental processes. This portfolio is now expanded by the report of a four-helix bundle protein able to store copper for particulate methane monooxygenase, an enzyme that catalyzes methane oxidation.
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Lombardi, A. Simple structure, complex function. Nat Chem Biol 11, 760–761 (2015). https://doi.org/10.1038/nchembio.1918