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Simple structure, complex function

The four-helix bundle is a simple structural motif, widespread in nature, that is involved in numerous and fundamental processes. This portfolio is now expanded by the report of a four-helix bundle protein able to store copper for particulate methane monooxygenase, an enzyme that catalyzes methane oxidation.

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Figure 1: Csp1-dependent methane monooxygenation.

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Correspondence to Angela Lombardi.

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Lombardi, A. Simple structure, complex function. Nat Chem Biol 11, 760–761 (2015).

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