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Host-directed drug therapy for tuberculosis

Chemical compounds designed to enhance understanding of host-pathogen interaction together with next-generation 'smart drugs' will rationally drive the discovery of promising new host-directed targets against pathogens including Mycobacterium tuberculosis, the causative agent of tuberculosis.

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Figure 1: Mtb host-evasion mechanism and potential host cellular cytosolic protein-directed targets.


Figure 2: Potential epigenomic, miRNA and lncRNA host-directed targets against Mtb.



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We thank M. Ozturk and O. Tamgue for critical reading of the manuscript. This work was supported by a National Research Foundation (NRF) of South Africa grant and by the Department of Science and Technology (DST), South African Research Chair Initiative, South African Medical Research Council (SAMRC), the NRF Competitive Programme for Unrated Researchers, DST/NRF Collaborative Postgraduate Training Programme and SAMRC Self-initiated Research Grant.

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Correspondence to Frank Brombacher.

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Guler, R., Brombacher, F. Host-directed drug therapy for tuberculosis. Nat Chem Biol 11, 748–751 (2015).

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