A new small-molecule inhibitor of the autophagy-initiating kinase ULK1 serves to block a critical survival mechanism activated upon inhibition of mTORC1, potentially enhancing treatment efficacy for mTOR inhibitors currently in clinical trials for cancer treatment.
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Goodwin, J., Murphy, L. bULKing up mTOR inhibition. Nat Chem Biol 11, 758–760 (2015). https://doi.org/10.1038/nchembio.1909
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DOI: https://doi.org/10.1038/nchembio.1909
