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Protein degradation

Prime time for PROTACs

A Corrigendum to this article was published on 20 October 2015

This article has been updated

PROTACs are heterobifunctional small molecules that simultaneously bind a target protein and a ubiquitin ligase, enabling ubiquitination and degradation of the target. Major progress in developing potent and specific PROTACs has recently been reported, invigorating prospects for novel PROTAC-based therapies.

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Figure 1: PROTAC mechanism of action and modular structure.

Katie Vicari/Nature Publishing Group

Change history

  • 23 September 2015

    In the version of this article originally published, the protein ERRα was mislabeled as BRD4 in Figure 1 and its legend, and the citation of the figure in the text was misplaced. These errors have been corrected in the HTML and PDF versions of the article.


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Correspondence to Raymond J Deshaies.

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Competing interests

R.J.D. is co-founder of a company (Cleave Biosciences) that is developing therapeutics based on targeting enzymes in the ubiquitin-proteasome pathway. R.J.D. also holds stock in Cleave Biosciences and serves as a consultant and member of their Scientific Advisory Board.

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Deshaies, R. Prime time for PROTACs. Nat Chem Biol 11, 634–635 (2015).

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