News & Views | Published:

Methods

A small-molecule SMASh hit

Nature Chemical Biology volume 11, pages 637638 (2015) | Download Citation

There are many techniques that can be employed to control gene expression at the post-translational level. However, a novel system called SMASh (small molecule–assisted shutoff), which allows for chemically-induced degradation of target proteins, presents some distinct advantages.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    et al. Nat. Chem. Biol. 11, 713–720 (2015).

  2. 2.

    , & Chem. Biol. 21, 1238–1252 (2014).

  3. 3.

    & Cell Res. 21, 1152–1154 (2011).

  4. 4.

    , , , & Nat. Methods 6, 917–922 (2009).

  5. 5.

    et al. Proc. Natl. Acad. Sci. USA 98, 8554–8559 (2001).

  6. 6.

    et al. J. Virol. 85, 6106–6116 (2011).

  7. 7.

    , & Proc. Natl. Acad. Sci. USA 100, 14127–14132 (2003).

  8. 8.

    , , & Mol. Cell 6, 751–756 (2000).

  9. 9.

    , , , & PLoS ONE 9, e95101 (2014).

Download references

Author information

Affiliations

  1. Pengbo Zhou and Jeffrey Hannah are in the Department of Pathology, Weill Cornell Medical College, New York, New York, USA.

    • Jeffrey Hannah
    •  & Pengbo Zhou

Authors

  1. Search for Jeffrey Hannah in:

  2. Search for Pengbo Zhou in:

Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Pengbo Zhou.

About this article

Publication history

Published

DOI

https://doi.org/10.1038/nchembio.1886

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing