There are many techniques that can be employed to control gene expression at the post-translational level. However, a novel system called SMASh (small molecule–assisted shutoff), which allows for chemically-induced degradation of target proteins, presents some distinct advantages.
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References
Chung, H.K. et al. Nat. Chem. Biol. 11, 713–720 (2015).
Rakhit, R., Navarro, R. & Wandless, T.J. Chem. Biol. 21, 1238–1252 (2014).
Hannah, J. & Zhou, P. Cell Res. 21, 1152–1154 (2011).
Nishimura, K., Fukagawa, T., Takisawa, H., Kakimoto, T. & Kanemaki, M. Nat. Methods 6, 917–922 (2009).
Sakamoto, K.M. et al. Proc. Natl. Acad. Sci. USA 98, 8554–8559 (2001).
Romano, K.P. et al. J. Virol. 85, 6106–6116 (2011).
Zhang, J., Zheng, N. & Zhou, P. Proc. Natl. Acad. Sci. USA 100, 14127–14132 (2003).
Zhou, P., Bogacki, R., McReynolds, L. & Howley, P.M. Mol. Cell 6, 751–756 (2000).
Park, A., Won, S.T., Pentecost, M., Bartkowski, W. & Lee, B. PLoS ONE 9, e95101 (2014).
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Hannah, J., Zhou, P. A small-molecule SMASh hit. Nat Chem Biol 11, 637–638 (2015). https://doi.org/10.1038/nchembio.1886
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DOI: https://doi.org/10.1038/nchembio.1886
