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Probing the epigenome

Epigenetic chemical probes are having a strong impact in biological discovery and target validation. Systematic coverage of emerging epigenetic target classes with these potent, selective, cell-active chemical tools will profoundly influence understanding of the human biology and pathology of chromatin-templated mechanisms.

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Figure 1: Leveling the landscape of epigenetics research (a,b).
Figure 2: Epigenetic chemical probes are extensively used.
Figure 3: Chemical biology tools for epigenetic drug discovery.

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Correspondence to Stefan Knapp or Matthieu Schapira.

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Huston, A., Arrowsmith, C., Knapp, S. et al. Probing the epigenome. Nat Chem Biol 11, 542–545 (2015). https://doi.org/10.1038/nchembio.1871

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