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mRNA regulation

A patch for a splice

Nature Chemical Biology volume 11, pages 454–455 (2015)Cite this article

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The spliceosome is an immensely complex molecular machine tasked with stitching together coding regions of genes. New work reveals how a small molecule can affect this machinery in a model of spinal muscular atrophy, a disease linked to aberrant splicing.

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Figure 1: Identification of a compound enabling translation of functional SMN.

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Authors and Affiliations

  1. Benjamin L. Miller is in the Department of Dermatology, University of Rochester Medical Center, Rochester, New York, USA.,

    Benjamin L Miller

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  1. Benjamin L Miller
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Correspondence to Benjamin L Miller.

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The author declares no competing financial interests.

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Miller, B. A patch for a splice. Nat Chem Biol 11, 454–455 (2015). https://doi.org/10.1038/nchembio.1839

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