A terminal triple bond toolbox

Terminal triple bonds feature in natural products, but their biosynthesis is little known. Now a terminal acetylenase has been characterized for substrate specificity for the first time, and an application to 'bio-click' chemistry has been shown by incorporation of the moiety into natural product scaffolds.

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Figure 1: Biosynthesis of terminal alkynes.


  1. 1

    Minto, R.E. & Blacklock, B.J. Prog. Lipid Res. 47, 233–306 (2008).

    CAS  Article  Google Scholar 

  2. 2

    Zhu, X., Liu, J. & Zhang, W. Nat. Chem. Biol. 10.1038/nchembio.1718 (22 December 2014).

  3. 3

    Shanklin, J. & Cahoon, E.B. Annu. Rev. Plant Physiol. Plant Mol. Biol. 49, 611–641 (1998).

    CAS  Article  Google Scholar 

  4. 4

    Blacklock, B.J., Scheffler, B.E., Shepard, M.R., Jayasuriya, N. & Minto, R.E. J. Biol. Chem. 285, 28442–28449 (2010).

    CAS  Article  Google Scholar 

  5. 5

    Haritos, V.S. et al. Nat. Commun. 3, 1150 (2013).

    Article  Google Scholar 

  6. 6

    Edwards, D.J. et al. Chem. Biol. 11, 817–833 (2004).

    CAS  Article  Google Scholar 

  7. 7

    Sandy, M., Rui, Z., Gallagher, J. & Zhang, W. ACS Chem. Biol. 7, 1956–1961 (2012).

    CAS  Article  Google Scholar 

Download references

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Correspondence to Victoria S Haritos.

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Haritos, V. A terminal triple bond toolbox. Nat Chem Biol 11, 98–99 (2015).

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