Biosynthesis

A terminal triple bond toolbox

Terminal triple bonds feature in natural products, but their biosynthesis is little known. Now a terminal acetylenase has been characterized for substrate specificity for the first time, and an application to 'bio-click' chemistry has been shown by incorporation of the moiety into natural product scaffolds.

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Figure 1: Biosynthesis of terminal alkynes.

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Correspondence to Victoria S Haritos.

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Haritos, V. A terminal triple bond toolbox. Nat Chem Biol 11, 98–99 (2015). https://doi.org/10.1038/nchembio.1731

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