Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:


A carbonate architect emerges

Carbonates are known to exist in natural products, but their biosynthesis has not been linked to any enzymes. An unusual fungal Baeyer-Villiger monooxygenase CcsB is now revealed to catalyze an in-line carbonate formation via a two-step mechanism of oxygen atom insertions.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: The mechanism of carbonate formation catalyzed by CcsB.


  1. Walsh, C.T. & Wencewicz, T.A. Nat. Prod. Rep. 30, 175–200 (2013).

    Article  CAS  Google Scholar 

  2. Beam, M.P., Bosserman, M.A., Noinaj, N., Wehenkel, M. & Rohr, J. Biochemistry 48, 4476–4487 (2009).

    Article  CAS  Google Scholar 

  3. Tibrewal, N. et al. J. Am. Chem. Soc. 134, 18181–18184 (2012).

    Article  CAS  Google Scholar 

  4. Hu, Y. et al. Nat. Chem. Biol. 10.1038/nchembio.1527 (18 May 2014)

  5. Wang, P., Bashiri, G., Gao, X., Sawaya, M.R. & Tang, Y. J. Am. Chem. Soc. 135, 7138–7141 (2013).

    Article  CAS  Google Scholar 

  6. Tibrewal, N. et al. J. Am. Chem. Soc. 134, 18181–18184 (2012).

    Article  CAS  Google Scholar 

  7. Scherlach, K., Boettger, D., Remme, N. & Hertweck, C. Nat. Prod. Rep. 27, 869–886 (2010).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Yuhui Sun.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sun, Y. A carbonate architect emerges. Nat Chem Biol 10, 486–487 (2014).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing