Pluripotency

Citrullination unravels stem cells

Maintenance of the pluripotent stem cell state is regulated by the post-translational modification of histones. The discovery that citrullination of the linker histone H1 is critical to this process represents a new role for the protein arginine deiminases in development.

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Figure 1: PAD4 is a regulator of pluripotency gene expression through the conversion of arginine to citrulline in histones.

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Correspondence to Paul R Thompson.

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P.R.T. is a cofounder and consultant for Padlock Therapeutics.

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Slade, D., Subramanian, V. & Thompson, P. Citrullination unravels stem cells. Nat Chem Biol 10, 327–328 (2014). https://doi.org/10.1038/nchembio.1504

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