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Pluripotency

Citrullination unravels stem cells

Nature Chemical Biology volume 10, pages 327328 (2014) | Download Citation

Maintenance of the pluripotent stem cell state is regulated by the post-translational modification of histones. The discovery that citrullination of the linker histone H1 is critical to this process represents a new role for the protein arginine deiminases in development.

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Author information

Affiliations

  1. Daniel J. Slade, Venkataraman Subramanian and Paul R. Thompson are at the Scripps Research Institute, Department of Chemistry, Jupiter, Florida, USA.

    • Daniel J Slade
    • , Venkataraman Subramanian
    •  & Paul R Thompson

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Competing interests

P.R.T. is a cofounder and consultant for Padlock Therapeutics.

Corresponding author

Correspondence to Paul R Thompson.

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DOI

https://doi.org/10.1038/nchembio.1504

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