TRPM3 can permeate ions through two distinct pores—the central pore and a likely alternative 'omega pore'. Entry of ions through the alternative pore of TRPM3 contributes to pain generation, making it an attractive target for the design of new analgesics.
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Katie Vicari
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Liman, E. Pain enters through the side door. Nat Chem Biol 10, 171–172 (2014). https://doi.org/10.1038/nchembio.1470
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DOI: https://doi.org/10.1038/nchembio.1470
