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Cancer therapy

Altering mitochondrial properties

The mitochondrial permeability transition pore (mPTP) is a multiprotein complex that regulates cell death in multiple pathological conditions. The discovery of new critical components of the mPTP and the identification of anticancer drugs acting on mPTP opens new frontiers for mitochondrial medicine.

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Figure 1: Putative mechanisms through which THPN-TR3 complexes induce autophagic cell death.

Katie Vicari

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Correspondence to Guido Kroemer.

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Pinton, P., Kroemer, G. Altering mitochondrial properties. Nat Chem Biol 10, 89–90 (2014). https://doi.org/10.1038/nchembio.1440

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