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Cancer therapy

Altering mitochondrial properties

Nature Chemical Biology volume 10, pages 8990 (2014) | Download Citation

The mitochondrial permeability transition pore (mPTP) is a multiprotein complex that regulates cell death in multiple pathological conditions. The discovery of new critical components of the mPTP and the identification of anticancer drugs acting on mPTP opens new frontiers for mitochondrial medicine.

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Author information

Affiliations

  1. Paolo Pinton is in the Department of Morphology, Surgery and Experimental Medicine and the Section of Pathology, Oncology and Experimental Biology at the Interdisciplinary Center for the Study of Inflammation (ICSI), Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy.

    • Paolo Pinton
  2. Guido Kroemer is at the Université Paris Descartes, Sorbonne Paris, Paris, France; the Metabolomics and Cell Biology Platforms, Institut Gustave-Roussy, Villejuif, France; INSERM, Centre de Recherche des Cordeliers, Paris, France; and Pôle de Biologie, Hôpital Européen Georges Pompidou, Paris, France.

    • Guido Kroemer

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Guido Kroemer.

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DOI

https://doi.org/10.1038/nchembio.1440

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