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Antigenic peptides

Reviving nuclear translation

Noncanonical translation of prespliced mRNA provides physiological meaning to nuclear translation in generating antigenic peptide substrates for the endogenous major histocompatibility complex class I pathway.

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Figure 1: Model for antigenic MHC class I peptide substrate generation.


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Correspondence to Petra Van Damme.

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The authors declare no competing financial interests.

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Van Damme, P., Menschaert, G. Reviving nuclear translation. Nat Chem Biol 9, 759–760 (2013).

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