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Metabolomics

Playing piñata with single cells

Nature Chemical Biology volume 9, pages 471–473 (2013)Cite this article

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Mass spectrometry advances in single-cell metabolomics enable the discovery of a new biological insight that is not accessible from population-level studies. A new study reveals that single baker's yeast cells provide sufficient material to study chemical and genetic inhibition of glycolysis and identifies metabolic subpopulations that would be invisible in bulk.

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Figure 1: Analysis of metabolites by MALDI-TOF MS in single yeast cells.

Katie Vicari

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Authors and Affiliations

  1. Oscar Yanes is at the Centre for Omic Sciences, Rovirai Virgili University, Reus, Spain and the Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Barcelona, Spain.,

    Oscar Yanes

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  1. Oscar Yanes
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Correspondence to Oscar Yanes.

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Yanes, O. Playing piñata with single cells. Nat Chem Biol 9, 471–473 (2013). https://doi.org/10.1038/nchembio.1297

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