Protein dynamics

Catch them if you can

A Corrigendum to this article was published on 17 June 2013

This article has been updated (view changelog)

NMR analysis of the conformational energy landscape of the catabolite activator protein suggests that allosteric inhibition can be achieved by blocking access to elusive high-energy states of proteins.

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Figure 1: Schematic of the conformational energy landscape of CAP*.

Change history

  • 21 May 2013

    In the version of this article initially published online, the imprecise term 'configurational entropy' was used in the middle of the first paragraph. The correct term is 'conformational entropy'. The error has been corrected for the print, PDF and HTML versions of this article.

References

  1. 1

    Frauenfelder, H. et al. Science 254, 1598–1603 (1991).

    CAS  Article  Google Scholar 

  2. 2

    Tsai, C.J. et al. Protein Sci. 8, 1181–1190 (1999).

    CAS  Article  Google Scholar 

  3. 3

    Baldwin, A.J. & Kay, L.E. Nat. Chem. Biol. 5, 808–814 (2009).

    CAS  Article  Google Scholar 

  4. 4

    Palmer, A.G. 3rd Chem. Rev. 104, 3623–3640 (2004).

    CAS  Article  Google Scholar 

  5. 5

    Bouvignies, G. et al. Nature 477, 111–134 (2011).

    CAS  Article  Google Scholar 

  6. 6

    Mulder, F.A.A. et al. Nat. Struct. Biol. 8, 932–935 (2001).

    CAS  Article  Google Scholar 

  7. 7

    Boehr, D.D. et al. Science 313, 1638–1642 (2006).

    CAS  Article  Google Scholar 

  8. 8

    Masterson. L.R. et al. J. Mol. Biol. 412, 155–164 (2011).

    CAS  Article  Google Scholar 

  9. 9

    Li, P. et al. Nat. Struct. Mol. Biol. 15, 613–618 (2008).

    CAS  Article  Google Scholar 

  10. 10

    Tzeng, S.-R. & Kalodimos, C.G. Nat. Chem. Biol. 10.1038/nchembio.1250 (5 May 2013).

Download references

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Correspondence to Gianluigi Veglia.

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Veglia, G. Catch them if you can. Nat Chem Biol 9, 410–411 (2013). https://doi.org/10.1038/nchembio.1258

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