NMR analysis of the conformational energy landscape of the catabolite activator protein suggests that allosteric inhibition can be achieved by blocking access to elusive high-energy states of proteins.
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Change history
21 May 2013
In the version of this article initially published online, the imprecise term 'configurational entropy' was used in the middle of the first paragraph. The correct term is 'conformational entropy'. The error has been corrected for the print, PDF and HTML versions of this article.
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Veglia, G. Catch them if you can. Nat Chem Biol 9, 410–411 (2013). https://doi.org/10.1038/nchembio.1258
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DOI: https://doi.org/10.1038/nchembio.1258
