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Structural biology

Protein self-assembly intermediates

Nature Chemical Biology volume 9, pages 216217 (2013) | Download Citation

Proteins can self-assemble into functional states, or they can end up as aberrant and sometimes toxic aggregates. Metastable intermediate states are often detected in these processes, and their structural characterization provides vital information about the balance between functional and pathological behavior in living systems.

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Author information

Affiliations

  1. Michele Vendruscolo and Christopher M. Dobson are at the Department of Chemistry, University of Cambridge, Cambridge, UK.

    • Michele Vendruscolo
    •  & Christopher M Dobson

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Competing interests

The authors declare no competing financial interests.

Corresponding authors

Correspondence to Michele Vendruscolo or Christopher M Dobson.

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DOI

https://doi.org/10.1038/nchembio.1210

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