Physiologically relevant ligands for mammalian odorant receptors have been elusive. A mouse odorant receptor–based bioassay has now been used to guide purification and identification of a natural ligand that mediates attraction of female mice to male urine.
This is a preview of subscription content, access via your institution
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Rent or buy this article
Get just this article for as long as you need it
Prices may be subject to local taxes which are calculated during checkout
Yoshikawa, K., Nakagawa, H., Mori, N., Watanabe, H. & Touhara, K. Nat. Chem. Biol. 9, 160–162 (2013).
Buck, L. & Axel, R. Cell 65, 175–187 (1991).
Zhao, H. et al. Science 279, 237–242 (1998).
Touhara, K. Neurochem. Int. 51, 132–139 (2007).
Li, J., Haddad, R., Chen, S., Santos, V. & Luetje, C.W. J. Neurochem. 121, 881–890 (2012).
Saito, H., Chi, Q., Zhuang, H., Matsunami, H. & Mainland, J.D. Sci. Signal. 2, ra9 (2009).
Uezono, Y. et al. Receptors Channels 1, 233–241 (1993).
Miura, N., Nakagawa, T., Tatsuki, S., Touhara, K. & Ishikawa, Y. Int. J. Biol. Sci. 5, 319–330 (2009).
Leal, W.S. Annu. Rev. Entomol. 58, 373–391 (2013).
Sato, K., Pellegrino, M., Nakagawa, T., Vosshall, L.B. & Touhara, K. Nature 452, 1002–1006 (2008).
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Luetje, C. Chemical courtship in mice. Nat Chem Biol 9, 140–141 (2013). https://doi.org/10.1038/nchembio.1180