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A public-private partnership to unlock the untargeted kinome

Chemical probes are urgently needed to functionally annotate hitherto-untargeted kinases and stimulate new drug discovery efforts to address unmet medical needs. The size of the human kinome combined with the high cost associated with probe generation severely limits access to new probes. We propose a large-scale public-private partnership as a new approach that offers economies of scale, minimized redundancy and sharing of risk and cost.

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Figure 1: Value chain of kinase inhibitors based on validation for biological investigations.


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Correspondence to William J Zuercher.

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Competing interests

S.K. and A.E. are in the Structural Genomics Consortium, an organization that is funded in part to generate research tools and place them in the public domain without restriction on use. J.B. and P.W. are employees of the Institute of Cancer Research, which has a commercial interest in inhibitors of several kinases. P.W. has relevant commercial interactions with Piramed Pharma, Genentech, Chroma Therapeutics, Sareum, Cyclacel, Astex Pharmaceuticals and AstraZeneca.

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Knapp, S., Arruda, P., Blagg, J. et al. A public-private partnership to unlock the untargeted kinome. Nat Chem Biol 9, 3–6 (2013).

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