A metabolic route including a RubisCO-like protein links polyamine metabolism with isoprenoid biosynthesis in the photosynthetic bacterium Rhodospirillum rubrum. Methanethiol is released in the pathway but is recaptured in the form of methionine, and thus methylthioadenosine, previously regarded as something of a byproduct of polyamine biosynthesis, is converted to two major cell components.
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References
Hartman, F.C. & Harpel, M.R. Annu. Rev. Biochem. 63, 197–234 (1994).
Shively, J.M., van Keulen, G. & Meijer, W.G. Annu. Rev. Microbiol. 52, 191–230 (1998).
Erb, T.J. et al. Nat. Chem. Biol. 8, 926–932 (2012)
Tabita, F.R. et al. Microbiol. Mol. Biol. Rev. 71, 576–599 (2007).
Finn, M.W. & Tabita, F.R. J. Bacteriol. 186, 6360–6366 (2004).
Sato, T., Atomi, H. & Imanaka, T. Science 315, 1003–1006 (2007).
Hanson, T.E. & Tabita, F.R. Proc. Natl. Acad. Sci. USA 98, 4397–4402 (2001).
Ashida, H. et al. Science 302, 286–290 (2003).
Imker, H.J., Singh, J., Warlick, B.P., Tabita, F.R. & Gerlt, J.A. Biochemistry 47, 11171–11173 (2008).
Singh, J. & Tabita, F.R. J. Bacteriol. 192, 1324–1331 (2010).
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Atomi, H. Nothing to waste. Nat Chem Biol 8, 877–878 (2012). https://doi.org/10.1038/nchembio.1089
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DOI: https://doi.org/10.1038/nchembio.1089
