Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Lipids

Tafazzin senses curvature

The phospholipid-lysophospholipid transacylase tafazzin is responsible for enrichment of the cardiolipin fraction of mitochondria with tetralinoleoyl-cardiolipin. The specificity for linoleoyl hydrocarbon chains is now explained by the specific action of tafazzin on negatively curved lipid monolayers.

Your institute does not have access to this article

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: Schematic presentation of a mitochondrion.

References

  1. Barth, P.G. et al. J. Neurol. Sci. 62, 327–355 (1983).

    CAS  Article  Google Scholar 

  2. Bione, S. et al. Nat. Genet. 12, 385–389 (1996).

    CAS  Article  Google Scholar 

  3. Schlame, M. et al. Nat. Chem. Biol. 8, 862–869 (2012).

    CAS  Article  Google Scholar 

  4. Claypool, S.M., McCaffery, J.M. & Koehler, C.M. J. Cell Biol. 174, 379–390 (2006).

    CAS  Article  Google Scholar 

  5. Neuwald, A.F. Curr. Biol. 7, R465–R466 (1997).

    CAS  Article  Google Scholar 

  6. Xu, Y., Malhotra, A., Ren, M.D. & Schlame, M. J. Biol. Chem. 281, 39217–39224 (2006).

    CAS  Article  Google Scholar 

  7. Schlame, M. et al. Ann. Neurol. 51, 634–637 (2002).

    CAS  Article  Google Scholar 

  8. Acehan, D. et al. Mitochondrion 9, 86–95 (2009).

    CAS  Article  Google Scholar 

  9. Malhotra, A., Xu, Y., Ren, M. & Schlame, M. Biochim. Biophys. Acta 1791, 314–320 (2009).

    CAS  Article  Google Scholar 

  10. Renner, L.D. & Weibel, D.B. Proc. Natl. Acad. Sci. USA 108, 6264–6269 (2011).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Klaus Gawrisch.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Gawrisch, K. Tafazzin senses curvature. Nat Chem Biol 8, 811–812 (2012). https://doi.org/10.1038/nchembio.1068

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nchembio.1068

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing