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Tafazzin senses curvature

The phospholipid-lysophospholipid transacylase tafazzin is responsible for enrichment of the cardiolipin fraction of mitochondria with tetralinoleoyl-cardiolipin. The specificity for linoleoyl hydrocarbon chains is now explained by the specific action of tafazzin on negatively curved lipid monolayers.

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Figure 1: Schematic presentation of a mitochondrion.


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Correspondence to Klaus Gawrisch.

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Gawrisch, K. Tafazzin senses curvature. Nat Chem Biol 8, 811–812 (2012).

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