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Lipids

Tafazzin senses curvature

Nature Chemical Biology volume 8, pages 811–812 (2012)Cite this article

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The phospholipid-lysophospholipid transacylase tafazzin is responsible for enrichment of the cardiolipin fraction of mitochondria with tetralinoleoyl-cardiolipin. The specificity for linoleoyl hydrocarbon chains is now explained by the specific action of tafazzin on negatively curved lipid monolayers.

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Figure 1: Schematic presentation of a mitochondrion.

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  1. Klaus Gawrisch is at the Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, US National Institutes of Health, Bethesda, Maryland, USA.,

    Klaus Gawrisch

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  1. Klaus Gawrisch
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Correspondence to Klaus Gawrisch.

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The author declares no competing financial interests.

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Gawrisch, K. Tafazzin senses curvature. Nat Chem Biol 8, 811–812 (2012). https://doi.org/10.1038/nchembio.1068

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