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Microbiology

GhoSTly bacterial persisters

Bacterial persisters consist of a phenotypic subpopulation that survives antibiotic treatment, prolonging infection. The GhoT toxin from the newly discovered ghoS-ghoT toxin-antitoxin system contributes to persistence, most likely by interfering with bacterial inner membrane integrity.

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Figure 1: Model for persistence and possible interplay between the MqsR toxin and the ghoST system.

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Correspondence to Laurence Van Melderen.

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Van Melderen, L. GhoSTly bacterial persisters. Nat Chem Biol 8, 812–813 (2012). https://doi.org/10.1038/nchembio.1066

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