Type IV collagen, a major constituent of basement membranes, contains an unusual intermolecular sulfilimine crosslink whose route of biosynthesis has remained undefined. An oxidative triad consisting of peroxidasin, H2O2 and halide is now shown to drive sulfilimine generation in vivo.
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Weiss, S. Tying the collagen-sulfilimine knot. Nat Chem Biol 8, 740–741 (2012). https://doi.org/10.1038/nchembio.1050
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DOI: https://doi.org/10.1038/nchembio.1050
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