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Sensing stability

Bacterial pili are surface fibers that must resist high shearing forces to remain associated with their target. The Escherichia coli type 1 pilus chaperone FimC serves as a 'sensor', ensuring that only stable pilins become incorporated into the growing fiber.

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Figure 1: 'Snapshot' model of type 1 pilus formation, including folding of FimA and its incorporation into the pilus fiber at the FimD usher.


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Correspondence to Andréa Dessen.

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Neves, D., Dessen, A. Sensing stability. Nat Chem Biol 8, 681–682 (2012).

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