Intrinsically disordered proteins and complex multidomain proteins are characterized by a dynamic ensemble of conformations that cannot be unequivocally described by traditional static terms of structural biology. The functional importance of this structural complexity necessitates new standards and protocols for the description and deposition of such 'supertertiary' structural ensembles into structural databases.
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Acknowledgements
This work was supported by the Research Foundation Flanders (FWO) Odysseus grant G.0029.12. The author is grateful to A. Bekesi for helpful discussions and to S. Kosol for her help in preparing the figures.
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Tompa, P. On the supertertiary structure of proteins. Nat Chem Biol 8, 597–600 (2012). https://doi.org/10.1038/nchembio.1009
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DOI: https://doi.org/10.1038/nchembio.1009