Modular polyketide synthases are intensively studied as exquisite synthetic machines generating bioactive natural products. The enoylreductase, a common component of these machines, has been structurally and functionally characterized, revealing a new complex architecture.
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References
Kwan, D.H. et al. Chem. Biol. 15, 1231–1240 (2008).
Kwan, D.H. & Leadlay, P.F. ACS Chem. Biol. 5, 829–838 (2010).
Zheng, J., Gay, D.C., Demeler, B., White, M.A. & Keatinge-Clay, A.T. Nat. Chem. Biol. 8, 615–621 (2012).
Keatinge-Clay, A.T. & Stroud, R.M. Structure 14, 737–748 (2006).
Reid, R. et al. Biochemistry 42, 72–79 (2003).
Baerga-Ortiz, A. et al. Chem. Biol. 13, 277–285 (2006).
Keatinge-Clay, A. J. Mol. Biol. 384, 941–953 (2008).
Waldron, C. et al. Chem. Biol. 8, 487–499 (2001).
Maier, T., Leibundgut, M. & Ban, N. Science 321, 1315–1322 (2008).
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Arakawa, K. Diversity between PKS and FAS. Nat Chem Biol 8, 604–605 (2012). https://doi.org/10.1038/nchembio.1007
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DOI: https://doi.org/10.1038/nchembio.1007
