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Protein evolution

The enzyme perfected

Nature Chemical Biology volume 8, pages 607608 (2012) | Download Citation

The origin of the flavonoid biosynthetic enzyme chalcone isomerase has remained a mystery. A combination of phylogenetic analysis, crystallography, biochemistry and genetics has uncovered how a stereospecific chalcone isomerase could have evolved from a nonenzymatic ancestral gene.

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Author information

Affiliations

  1. Wendy Ann Peer is at the Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, Indiana, USA.

    • Wendy Ann Peer

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Competing interests

The author declares no competing financial interests.

Corresponding author

Correspondence to Wendy Ann Peer.

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DOI

https://doi.org/10.1038/nchembio.1006

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