News & Views | Published:

Peptide inhibitors

Four of a kind beats a pair

Nature Chemical Biology volume 8, pages 606607 (2012) | Download Citation

The proapoptotic cysteine protease caspase-6 participates in the neuropathology of several diseases. Unlike the active dimeric form, the caspase-6 zymogen forms a unique tetramer that can be stabilized by allosteric inhibitors, which prevents caspase-6 activation.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    & Biochem. J. 384, 201–232 (2004).

  2. 2.

    et al. Nat. Chem. Biol. 8, 655–660 (2012).

  3. 3.

    et al. Am. J. Pathol. 165, 523–531 (2004).

  4. 4.

    et al. Cell 125, 1179–1191 (2006).

  5. 5.

    et al. Hum. Mol. Genet. 20, 2770–2782 (2011).

  6. 6.

    et al. Hum. Mol. Genet. 21, 1954–1967 (2012).

  7. 7.

    et al. J. Cell Biol. 144, 281–292 (1999).

  8. 8.

    et al. EMBO Rep. 11, 841–847 (2010).

  9. 9.

    , , , & Proc. Natl. Acad. Sci. USA 101, 12461–12466 (2004).

  10. 10.

    et al. Biochem. J. 423, 429–439 (2009).

Download references

Author information

Affiliations

  1. Shawn B. Bratton is in the Department of Molecular Carcinogenesis at the University of Texas– M.D. Anderson Cancer Center, Science Park, Smithville, Texas, USA.

    • Shawn B Bratton

Authors

  1. Search for Shawn B Bratton in:

Competing interests

The author declares no competing financial interests.

Corresponding author

Correspondence to Shawn B Bratton.

About this article

Publication history

Published

DOI

https://doi.org/10.1038/nchembio.1000

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing