The proapoptotic cysteine protease caspase-6 participates in the neuropathology of several diseases. Unlike the active dimeric form, the caspase-6 zymogen forms a unique tetramer that can be stabilized by allosteric inhibitors, which prevents caspase-6 activation.
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Bratton, S. Four of a kind beats a pair. Nat Chem Biol 8, 606–607 (2012). https://doi.org/10.1038/nchembio.1000
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DOI: https://doi.org/10.1038/nchembio.1000
