Testing for enzymes is important for diagnosing various medical conditions but can be problematic because of the complexity of physiological media such as blood. Now, a method of detecting phospholipases has been developed that neatly couples their concentration with the aggregation of gold nanoparticles.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Change history
01 December 2010
In the version of this News & Views originally published, Fig. 1 was appearing incorrectly; this has now been corrected in the HTML and PDF versions.
References
Dennis, E. A. J. Bio. Chem. 269, 13057–13060 (1994).
Cordella-Miele, E., Miele, L. & Mukherjee, A. B. J. Bio. Chem. 265, 17180–17188 (1990).
Aili, D., Mager, M., Roche, D. & Stevens, M. M. Nano Lett. 10.1021/nl1024062 (2010).
Rex, S. & Schwarz, G. Biochemistry 37, 2336–2345 (1998).
Niemeyer, C. M. Angew. Chem. Int. Ed. 40, 4128–4158 (2001).
Aili, D. et al. J. Am. Chem. Soc. 128, 2194–2195 (2006).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Melosh, N. Detection by failure. Nature Chem 2, 1006–1007 (2010). https://doi.org/10.1038/nchem.914
Published:
Issue Date:
DOI: https://doi.org/10.1038/nchem.914
This article is cited by
-
Correction: Enzyme assays: Detection by failure
Nature Chemistry (2011)
