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Structure determination

Molecules under the microscope

A series of scanning probe microscopy experiments combined with density functional theory calculations have now been used to unambiguously determine the structure of a marine natural product. Can this method become generally useful for the determination of the structure of natural products?

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Figure 1: Possible structures of an unknown natural product4.
Figure 2: SPM measurements of a natural product structure4.

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Blunt, J. Molecules under the microscope. Nature Chem 2, 799–800 (2010). https://doi.org/10.1038/nchem.849

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