Natural product synthesis

Clearing the way to cortistatins

A versatile intermediate has been shown to provide access to a wide variety of compounds in the cortistatin family. This approach offers the most efficient total synthesis of the cortistatins reported so far.

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Figure 1: Total synthesis of cortistatins A, J, K and L.

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Sarpong, R. Clearing the way to cortistatins. Nature Chem 2, 803–804 (2010). https://doi.org/10.1038/nchem.802

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