Synthetic strategy

Moving backwards in new ways

Pattern mapping is a synthetic tactic that is complementary to standard retrosynthetic analysis. When combined with the concept of traceless stereochemical guidance, it leads to an efficient synthesis of the steroidal natural product (±)-aplykurodinone-1.

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Figure 1: Pattern mapping and traceless stereochemical guidance in the synthesis of aplykurodinone-1.

References

  1. 1

    Corey, E. J. & Cheng, X-M. The Logic of Chemical Synthesis (Wiley, 1989).

    Google Scholar 

  2. 2

    Wilson, R. M. & Danishefsky, S. J. J. Org. Chem. 72, 4293–4305 (2007).

    CAS  Article  Google Scholar 

  3. 3

    Zhang, Y. & Danishefsky, S. J. J. Am. Chem. Soc. 10.1021/ja1035495 (2010).

  4. 4

    Danishefsky, S. & Kitahara, T. J. Am. Chem. Soc. 96, 7807–7808 (1974).

    CAS  Article  Google Scholar 

  5. 5

    Mundal, D. A., Avetta, C. T. Jr & Thomson, R. J. Nature Chem. 2, 294–297 (2010).

    CAS  Article  Google Scholar 

  6. 6

    Steinhardt, S. E. & Vanderwal, C. D. Nature Chem. 2, 254–256 (2010).

    CAS  Article  Google Scholar 

Download references

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Correspondence to Rich G. Carter.

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Collett, N., Carter, R. Moving backwards in new ways. Nature Chem 2, 613–614 (2010). https://doi.org/10.1038/nchem.758

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