Synthetic strategy

Moving backwards in new ways

Pattern mapping is a synthetic tactic that is complementary to standard retrosynthetic analysis. When combined with the concept of traceless stereochemical guidance, it leads to an efficient synthesis of the steroidal natural product (±)-aplykurodinone-1.

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Figure 1: Pattern mapping and traceless stereochemical guidance in the synthesis of aplykurodinone-1.


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Correspondence to Rich G. Carter.

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Collett, N., Carter, R. Moving backwards in new ways. Nature Chem 2, 613–614 (2010).

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