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Towards artificial terpene cyclases

Nature Chemistry volume 2, pages 519–520 (2010)Cite this article

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The plant-derived sesquiterpene englerin A is a potent inhibitor of several renal cancer cell lines. Two recent total syntheses have utilized cationic gold(I)-complexes to coax readily available open-chain precursors into englerin's challenging oxotricyclic core with enzyme-like precision.

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Figure 1: Comparison of the biosynthesis and the total synthesis of englerin A.

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Authors and Affiliations

  1. Mathias Christmann and Matthieu Willot are at TU Dortmund University, Organic Chemistry, Otto-Hahn-Str. 6, D-44227 Dortmund, Germany. mathias.christmann@tu-dortmund.de,

    Matthieu Willot & Mathias Christmann

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  1. Matthieu Willot
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  2. Mathias Christmann
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Willot, M., Christmann, M. Towards artificial terpene cyclases. Nature Chem 2, 519–520 (2010). https://doi.org/10.1038/nchem.715

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