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Marine natural products

Totally tubular peptide synthesis

The convergent total synthesis of the pore-forming polytheonamide B — a linear peptide natural product — pokes holes through perceived limitations in de novo peptide synthesis, and provides access to novel synthetic membrane channels.

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Figure 1: Convergent total synthesis of polytheonamide B.

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Forsyth, C. Totally tubular peptide synthesis. Nature Chem 2, 252–254 (2010). https://doi.org/10.1038/nchem.603

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