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Natural-product synthesis

Stitching together palau'amine

Nature Chemistry volume 2, pages 159160 (2010) | Download Citation

The long-awaited first total synthesis of the structurally intriguing natural product palau'amine has now been achieved. The synthesis features cascade reactions and an 'across ring' stitching of a 'macropalau'amine', and sets the bar for future efforts towards an enantioselective variant.

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References

  1. 1.

    & Classics in Total Synthesis (Wiley-VCH, 1996).

  2. 2.

    & Classics in Total Synthesis II (Wiley-VCH, 2003).

  3. 3.

    , & J. Am. Chem. Soc. 115, 3376–3377 (1993).

  4. 4.

    , , & Angew. Chem. Int. Ed. 46, 6586–6594 (2007).

  5. 5.

    et al. Mar. Drugs 7, 705–753 (2009).

  6. 6.

    et al. Angew. Chem. Int. Ed. 49, 1095–1098 (2010).

  7. 7.

    , , , & Tetrahedron Lett. 40, 5519–5522 (1999).

  8. 8.

    & J. Am. Chem. Soc. 128, 3926–3927 (2006).

  9. 9.

    , & J. Am. Chem. Soc. 129, 9964–9975 (2007).

  10. 10.

    & Eur. J. Org. Chem. 237–243 (2001).

Download references

Author information

Affiliations

  1. Daniel Romo is in the Department of Chemistry at Texas A&M University, College Station, Texas 77842, USA. romo@tamu.edu

    • Daniel Romo

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DOI

https://doi.org/10.1038/nchem.565

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