The long-awaited first total synthesis of the structurally intriguing natural product palau'amine has now been achieved. The synthesis features cascade reactions and an 'across ring' stitching of a 'macropalau'amine', and sets the bar for future efforts towards an enantioselective variant.
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Romo, D. Stitching together palau'amine. Nature Chem 2, 159–160 (2010). https://doi.org/10.1038/nchem.565
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DOI: https://doi.org/10.1038/nchem.565
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