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Magnetic resonance imaging

Making sense of disassembly

An amphiphilic molecule that contains a protein-specific ligand and an NMR-active tag forms the basis of a protein sensor. A measurable NMR signal results only in the presence of active protein that causes disassembly of clusters of the amphiphile.

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Figure 1: Protein-induced disassembly of aggregates generates an NMR or MRI signal.


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Correspondence to S. Thayumanavan.

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Azagarsamy, M., Thayumanavan, S. Making sense of disassembly. Nature Chem 1, 523–524 (2009).

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