Organic synthesis

New uses for old building blocks

New methodology that couples together carbonyl compounds with boronic acids shows much promise for synthesis owing to ease of access of the building blocks, functional group tolerance and broad scope of the reaction.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Construction of complex chemical compounds from simple building blocks.
Figure 2: Successful and unsuccessful reactions of diazoesters with boron derivatives.


  1. 1

    Barluenga, J., Tomás-Gamasa, M., Aznar, F. & Valdés, C. Nature Chem. 1, 494–499 10/1038/nchem.328(2009).

    CAS  Article  Google Scholar 

  2. 2

    Hooz, J. & Linke, S. J. Am. Chem. Soc. 90, 5936–5937 (1968).

    CAS  Article  Google Scholar 

  3. 3

    Brown, H. C., Midland, M. M. & Levy, A. B. J. Am. Chem. Soc. 94, 3662–3664 (1972).

    CAS  Article  Google Scholar 

  4. 4

    Peng, C., Zhang, W., Yan, G. & Wang, J. Org. Lett. 11, 1667–1670 (2009).

    CAS  Article  Google Scholar 

  5. 5

    Closs, G. L. & Moss, R. A. J. Am. Chem. Soc. 86, 4042–4053 (1964).

    CAS  Article  Google Scholar 

  6. 6

    Fulton, J. R., Aggarwal, V. K. & de Vicente, J. Eur. J. Org. Chem. 1479–1492 (2005).

Download references

Author information



Rights and permissions

Reprints and Permissions

About this article

Cite this article

Aggarwal, V. New uses for old building blocks. Nature Chem 1, 433–434 (2009).

Download citation

Further reading


Quick links

Sign up for the Nature Briefing newsletter for a daily update on COVID-19 science.
Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing