Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Organic synthesis

New uses for old building blocks

New methodology that couples together carbonyl compounds with boronic acids shows much promise for synthesis owing to ease of access of the building blocks, functional group tolerance and broad scope of the reaction.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Construction of complex chemical compounds from simple building blocks.
Figure 2: Successful and unsuccessful reactions of diazoesters with boron derivatives.

References

  1. Barluenga, J., Tomás-Gamasa, M., Aznar, F. & Valdés, C. Nature Chem. 1, 494–499 10/1038/nchem.328(2009).

    Article  CAS  Google Scholar 

  2. Hooz, J. & Linke, S. J. Am. Chem. Soc. 90, 5936–5937 (1968).

    Article  CAS  Google Scholar 

  3. Brown, H. C., Midland, M. M. & Levy, A. B. J. Am. Chem. Soc. 94, 3662–3664 (1972).

    Article  CAS  Google Scholar 

  4. Peng, C., Zhang, W., Yan, G. & Wang, J. Org. Lett. 11, 1667–1670 (2009).

    Article  CAS  Google Scholar 

  5. Closs, G. L. & Moss, R. A. J. Am. Chem. Soc. 86, 4042–4053 (1964).

    Article  CAS  Google Scholar 

  6. Fulton, J. R., Aggarwal, V. K. & de Vicente, J. Eur. J. Org. Chem. 1479–1492 (2005).

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Aggarwal, V. New uses for old building blocks. Nature Chem 1, 433–434 (2009). https://doi.org/10.1038/nchem.346

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nchem.346

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing