Biosynthesis

Reprogramming assembly lines

Rational engineering of biosynthetic assembly lines for production of new compounds is an attractive prospect, yet it presents many challenges. Learning from biology, some of the rules for expanding the chemical diversity of non-ribosomal peptides have been uncovered in two recent studies.

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Figure 1: Reprogramming NRPS pathways by domain engineering and XU swapping.

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Correspondence to Binuraj R. K. Menon or Matthew Jenner.

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Menon, B., Jenner, M. Reprogramming assembly lines. Nature Chem 10, 245–247 (2018). https://doi.org/10.1038/nchem.2941

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