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Biosynthesis

Reprogramming assembly lines

Nature Chemistry volume 10, pages 245–247 (2018)Cite this article

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Rational engineering of biosynthetic assembly lines for production of new compounds is an attractive prospect, yet it presents many challenges. Learning from biology, some of the rules for expanding the chemical diversity of non-ribosomal peptides have been uncovered in two recent studies.

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Figure 1: Reprogramming NRPS pathways by domain engineering and XU swapping.

References

  1. Hur, G. H., Vickery, C. R. & Burkart, M. D. Nat. Prod. Rep. 29, 1074–1098 (2012).

    Article  CAS  Google Scholar 

  2. Winn, M., Fyans, J. K., Zhuo, Y. & Micklefield, J. Nat. Prod. Rep. 33, 317–347 (2016).

    Article  CAS  Google Scholar 

  3. Tanovic, A., Samel, S. A., Essen, L.-O. & Marahiel, M. A. Science 321, 659–663 (2008).

    Article  CAS  Google Scholar 

  4. Drake, E. J. et al. Nature 529, 235–238 (2016).

    Article  CAS  Google Scholar 

  5. Reimer, J. M., Aloise, M. N., Harrison, P. M. & Martin Schmeing, T. Nature 529, 239–242 (2016).

    Article  CAS  Google Scholar 

  6. Niquille, D. L. et al. Nat. Chem. 10, 282–287 (2018).

    Article  CAS  Google Scholar 

  7. Conti, E., Stachelhaus, T., Marahiel, M. A. & Brick, P. EMBO J. 16, 4174–4183 (1997).

    Article  CAS  Google Scholar 

  8. Stachelhaus, T., Mootz, H. D. & Marahiel, M. A. 6, 493–505 (1999).

  9. Challis, G. L., Ravel, J. & Townsend, C. A. Chem. Biol. 7, 211–224 (2000).

    Article  CAS  Google Scholar 

  10. Miyanaga, A., Cieślak, J., Shinohara, Y., Kudo, F. & Eguchi, T. J. Biol. Chem. 289, 31448–31457 (2014).

    Article  CAS  Google Scholar 

  11. Zhang, K. et al. Chem. Biol. 20, 92–101 (2013).

    Article  CAS  Google Scholar 

  12. Bozhüyük, K. A. J. et al. Nat. Chem. 10, 275–281 (2018).

    Article  Google Scholar 

  13. Zhang, L. et al. Angew. Chemie Int. Ed. 56, 1740–1745 (2017).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Warwick Integrative Synthetic Biology Centre, School of Life sciences, University of Warwick, Coventry, CV4 7AL, UK

    Binuraj R. K. Menon

  2. Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK

    Matthew Jenner

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  1. Binuraj R. K. Menon
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  2. Matthew Jenner
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Correspondence to Binuraj R. K. Menon or Matthew Jenner.

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Menon, B., Jenner, M. Reprogramming assembly lines. Nature Chem 10, 245–247 (2018). https://doi.org/10.1038/nchem.2941

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