Mass spectrometry

Raw protein from the top down

Mass spectrometry is a powerful technique for analysing proteins, yet linking higher-order protein structure to amino acid sequence and post-translational modifications is far from simple. Now, a native top-down method has been developed that can provide information on higher-order protein structure and different proteoforms at the same time.

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Figure 1: Native top-down mass spectrometry of protein complexes.

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Correspondence to Kathrin Breuker.

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Breuker, K. Raw protein from the top down. Nature Chem 10, 114–116 (2018). https://doi.org/10.1038/nchem.2936

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