Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Organic chemistry

A radical step forward

Free radicals are notorious for unselective coupling reactions; however, the coupling of free radicals generated from acyl tellurides has now been shown to form C–C bonds with remarkable fidelity, which enables easy one-step assembly of densely oxygenated natural product motifs.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Prices vary by article type



Prices may be subject to local taxes which are calculated during checkout

Figure 1: The coupling of free radicals.


  1. Qin, T. et al. Science 352, 801–805 (2016).

    Article  CAS  Google Scholar 

  2. Giese, B. et al. Liebigs Ann. Chem. 1988, 997–1000 (1988).

    Article  Google Scholar 

  3. Depew, K. M. et al. J. Am. Chem. Soc. 121, 11953–11963 (1999).

    Article  CAS  Google Scholar 

  4. Schäfer, H.-J. Top. Curr. Chem. 152, 91–151 (1990).

    Article  Google Scholar 

  5. Yamada, Y. & Momose, D.-i. Chem. Lett. 10, 1277–1278 (1981).

    Article  Google Scholar 

  6. Movassaghi, M. & Schmidt, M. Angew. Chem. Int. Ed. 46, 3725–3728 (2007).

    Article  CAS  Google Scholar 

  7. Fürstner, A. & Bogdanović, B. Angew. Chem. Int. Ed. 35, 2442–2469 (1996).

    Article  Google Scholar 

  8. Nicolaou, K. C. et al. Angew. Chem. Int. Ed. 48, 7140–7165 (2009).

    Article  CAS  Google Scholar 

  9. Nagatomo, M. et al. Angew. Chem. Int. Ed. 54, 1537–1541 (2015).

    Article  CAS  Google Scholar 

  10. Nagatomo, M. et al. Chem. Sci. 6, 2765–2769 (2015).

    Article  CAS  Google Scholar 

  11. Matsumura, S. et al. Tetrahedron 72, 4859–4866 (2016).

    Article  CAS  Google Scholar 

  12. Masuda, K., Nagatomo, M. & Inoue, M. Nat. Chem. 9, 207–212 (2017).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Ang Li.

Rights and permissions

Reprints and Permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Zhang, W., Li, A. A radical step forward. Nature Chem 9, 198–199 (2017).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing