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C–H activation

Complex peptides made simple

Nature oxidizes biosynthetic intermediates into structurally and functionally diverse peptides. An iron-catalysed C–H oxidation mimics this approach in the lab, enabling chemists to synthesize structural analogues with ease.

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Figure 1: Oxidative diversification of amino acids and peptides by small-molecule iron catalysis.


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Correspondence to David R. Spring.

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Bartlett, S., Spring, D. Complex peptides made simple. Nature Chem 9, 9–10 (2017).

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