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C–H activation

Complex peptides made simple

Nature oxidizes biosynthetic intermediates into structurally and functionally diverse peptides. An iron-catalysed C–H oxidation mimics this approach in the lab, enabling chemists to synthesize structural analogues with ease.

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Figure 1: Oxidative diversification of amino acids and peptides by small-molecule iron catalysis.

References

  1. Hoffmann, T. & Fosgerau, K. Drug Discov. Today 20, 122–128 (2015).

    Article  Google Scholar 

  2. Ling, L. L. et al. Nature 517, 455–459 (2015).

    Article  CAS  Google Scholar 

  3. Walsh, C. & Wencewicz, T. Antibiotics: Challenges, Mechanisms, Opportunities (American Society for Microbiology, 2016).

    Google Scholar 

  4. Winn, M, Fryans, J. K., Zhuo, Y. & Micklefield, J. J. Nat. Prod. Rep. 33, 317–347 (2016).

    Article  CAS  Google Scholar 

  5. Fischbach, M. A. & Walsh, C. T. Chem. Rev. 106, 3468–3496 (2006).

    Article  CAS  Google Scholar 

  6. Walsh, C. T. et al. Curr. Opin. Chem. Biol. 5, 525–534 (2001).

    Article  CAS  Google Scholar 

  7. Bartlett, P. A. & Entzeroth, M. (eds) Exploiting Chemical Diversity for Drug Discovery (Royal Society of Chemistry, 2006).

    Book  Google Scholar 

  8. Osberger, T. J., Rogness, D. C., Kohrt, J. T., Stepan, A. F. & White, M. C. Nature 537, 214–219 (2016).

    Article  CAS  Google Scholar 

  9. Barton, D. H. R. & Doller, D. Acc. Chem. Res. 25, 504–512 (1992).

    Article  CAS  Google Scholar 

  10. Chuang, K. V., Xu, C. & Reisman, S. E. Science 353, 912–915 (2016).

    Article  CAS  Google Scholar 

  11. Yudin, A. K. Chem. Sci. 6, 30–49 (2015).

    Article  CAS  Google Scholar 

  12. Over, B. et al. Nat. Chem. Biol. 12, 1065–1074 (2016).

    Article  CAS  Google Scholar 

  13. Burns, M. et al. Nature 513, 183–188 (2014).

    Article  CAS  Google Scholar 

Download references

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Correspondence to David R. Spring.

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Bartlett, S., Spring, D. Complex peptides made simple. Nature Chem 9, 9–10 (2017). https://doi.org/10.1038/nchem.2701

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