Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Antibody–drug conjugates

The missing link

The targeted release of bioactive molecules to diseased tissues has the potential to improve therapeutic efficacy, but not all drugs contain a free functional group that can be easily attached to an antibody. Now, a linker technology has been developed to enable the traceless release of tertiary and heteroaryl amine-containing drugs.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Targeted delivery of tertiary and heteroaryl amine-containing drugs.


  1. Chudasama, V., Maruani, A. & Caddick, S. Nat. Chem. 8, 114–119 (2016).

    Article  CAS  Google Scholar 

  2. Rodrigues, T., Reker, D., Schneider, P. & Schneider, G. Nat. Chem. 8, 531–541 (2016).

    Article  CAS  Google Scholar 

  3. Staben, L. R. et al. Nat. Chem. 8, 1112–1119 (2016).

    Article  CAS  Google Scholar 

  4. Burke, P. J. et al. Mol. Cancer Ther. 15, 938–945 (2016).

    Article  CAS  Google Scholar 

  5. Lehar, S. M. et al. Nature 527, 323–328 (2015).

    Article  CAS  Google Scholar 

  6. Baell, J. B. & Holloway, G. A. J. Med. Chem. 53, 2719–2740 (2010).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Gonçalo J. L. Bernardes.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Rodrigues, T., Bernardes, G. The missing link. Nature Chem 8, 1088–1090 (2016).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research