Three different methods that use a single ruthenium catalyst to enable the facile formation of meta- and para-substituted alkenylarenes have now been developed. The reactions proceed through a tandem alkenylation/decarboxylation process and provide several advantages over alternative approaches.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Labinger, J. A. & Bercaw, J. E. Nature 417, 507–514 (2002).
Alberico, D., Scott, M. E. & Lautens, M. Chem. Rev. 107, 174–238 (2007).
Yang, J. Org. Biomol. Chem. 13, 1930–1941 (2015).
Cornella, J. & Larrosa, I. Synthesis 5, 653–676 (2012).
Rousseau, G. & Breit, B. Angew. Chem. Int. Ed. 50, 2450–2494 (2011).
Zhang, J., Shrestha, R., Hartwig, J. F. & Zhao, P. Nat. Chem. 8, 1144–1151 (2016).
Kumar, N. Y. P., Bechtoldt, A., Raghuvanshi, K. & Ackermann, L. Angew. Chem. Int. Ed. 55, 6929–6932 (2016).
Huang, L., Biafora, A., Zhang, G., Bragoni, V. & Gooßen, L. J. Angew. Chem. Int. Ed. 55, 6933–6937 (2016).
Nevado, C. & Echavarren, A. M. Synthesis 2, 167–182 (2005).
Grainger, R., Cornella, J., Blakemore, D. C., Larrosa, I. & Campanera, J. M. Chem. Eur. J. 20, 16680–16687 (2014).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Simonetti, M., Larrosa, I. Good things come in threes. Nature Chem 8, 1086–1088 (2016). https://doi.org/10.1038/nchem.2679
Published:
Issue Date:
DOI: https://doi.org/10.1038/nchem.2679
This article is cited by
-
Merging C–H and C–C bond cleavage in organic synthesis
Nature Reviews Chemistry (2017)