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C–H activation

Good things come in threes

Three different methods that use a single ruthenium catalyst to enable the facile formation of meta- and para-substituted alkenylarenes have now been developed. The reactions proceed through a tandem alkenylation/decarboxylation process and provide several advantages over alternative approaches.

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Figure 1: Carboxylic acids as traceless directing groups.


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Correspondence to Igor Larrosa.

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Simonetti, M., Larrosa, I. Good things come in threes. Nature Chem 8, 1086–1088 (2016).

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